Moving Targets in Hepatocellular Carcinoma: Hepatic Progenitor Cells as Novel Targets for Tyrosine Kinase Inhibitors
نویسندگان
چکیده
منابع مشابه
CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic targets for HCC. In this study, we found that checkpoint kinase 1 (CHK1) was frequently overexpressed and correlated with poor clinical outcome in patients with HCC. We further showed that the CHK1 inhibitor GÖ6976 was ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2008
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2008.07.036